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Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the almost uniformly lethal brain tumor. Their findings, reported in Nature Medicine, identify macrophages that express high levels of CD73, a […]
Unlike almost every other organ, the mammary gland does not develop until after birth. And it’s unusually dynamic, shape-shifting during menstrual cycles, puberty, pregnancy, and lactation. These changes require energy. In a study using a new, genetically altered mouse model, researchers led by Rumela Chakrabarti of Penn’s School of Veterinary Medicine have uncovered a key […]
Research led by Nicolas Bazan, MD, Ph.D., Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, found a new mechanism by which a class of molecules his lab discovered may protect brain and retinal cells against neurodegenerative diseases like age-related macular degeneration and Alzheimer’s. Results, published […]
An international team of researchers has found a different way cancer becomes resistant to chemotherapy, suggesting a new target for drugs. Chemotherapy kills cancers cells by preventing them from multiplying and by inducing ‘cell death’, a natural process that can be enhanced with drugs. One form of cell death, called ferroptosis—iron-dependent cell death—is caused by […]
Your immune system’s natural killer cells recognize and attack two major kinds of danger—cells infected by viruses and cells affected by cancer. When natural killer (NK) cells see a cancer cell, they kill it (naturally…). And a major research focus has been to define how NK cells do this “seeing.” One way NK cells see […]
Adelaide researchers are homing in on a new treatment target for the aggressive blood cancer multiple myeloma. The University of Adelaide’s SAHMRI-based Myeloma Research Laboratory’s studies, published in Neoplasia, demonstrated for the first time the importance of white blood cells called macrophages for the disease’s ability to establish and proliferate. Lead author and Ph.D. student […]
When we found out that we were expecting a baby girl, my brain started running wild with so many questions. What would I name her? How fast can I get to the mall to buy her first outfit? What should her nursery look like? So. Many. QUESTIONS. We had just bought a new home, so […]