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KU Leuven researchers have identified the biological mechanism that explains why some people experience abdominal pain when they eat certain foods. The finding paves the way for more efficient treatment of irritable bowel syndrome and other food intolerances. The study, carried out in mice and humans, was published in Nature. Up to 20% of the […]
Scientists have known for years that mutations in the MLL4 gene can cause Kabuki syndrome, a rare developmental disorder. But a study published on Jan. 11 in Nature Communications illuminates new details regarding how this occurs. The research suggests that MLL4 controls the production of neurons that secrete growth hormone-releasing hormone (GHRH) in a part […]
Neuroscientists at UCL have found no significant association between COVID-19 and the potentially paralysing and sometimes fatal neurological condition Guillain-Barré syndrome. Researchers say the findings, published in the journal Brain, along with a linked scientific commentary by UCL and other international experts, should provide the public with reassurance, as the UK’s national coronavirus vaccination programme […]
A new drug discovered through a research collaboration between the University at Buffalo and Tetra Therapeutics took a major step toward becoming a first-in-class treatment for Fragile X Syndrome, a leading genetic cause of autism. The drug, BPN14770, achieved positive topline results in a phase 2 clinical study. The innovative treatment improved cognitive function in […]
(HealthDay)—When adults with Down syndrome contract COVID-19, their risk of dying is much higher than the norm, a large, new study finds. The researchers found that of over 8 million British adults, those with Down syndrome were four times more likely to be hospitalized with COVID-19, and 10 times more likely to die due to […]
A key mechanism underlying neuronal dysfunction in Angelman syndrome (AS), a syndromic form of autism spectrum disorder, has—for the first time—been revealed through innovative research led by Duke-NUS Medical School and the National Neuroscience Institute (NNI) under the National Neuroscience Research Institute Singapore (NNRIS)—a joint venture combining neuroscience research expertise from both organisations. The finding […]
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Compounds from hops may combat metabolic syndrome by changing the gut microbiome and altering the metabolism of acids produced in the liver, new research at Oregon State University suggests. The findings, published in Molecular Nutrition and Food Research, are a key advance in understanding how xanthohumol, a compound that contributes to hops’ flavor, and its […]
Professor Juan Lerma’s group, from the UMH-CSIC Institute of Neurosciences, in Alicante (Spain), has identified the gene called GRIK1, fundamental in the balance between excitation and inhibition in the brain, as one of the causes for people with Down syndrome having spatial orientation problems. The GRIK1 gene is located on chromosome 21, which is triplicated […]