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Novel drug delivery particles use neurotransmitters as a ‘passport’ into the brain
Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice. The innovation, published today in Science Advances, could overcome many of the current limitations encountered in delivering […]
Novel treatment using patient’s own cells opens new possibilities to treat Parkinson’s disease
Reprogramming a patient’s own skin cells to replace cells in the brain that are progressively lost during Parkinson’s disease (PD) has been shown to be technically feasible, reports a team of investigators from McLean Hospital and Massachusetts General Hospital (MGH) in the most recent issue of the New England Journal of Medicine. PD is the […]
Novel coronavirus case numbers ‘stabilising’: WHO
The number of cases of the deadly novel coronavirus being reported on a daily basis in China is “stabilising”, the World Health Organization said on Saturday. The UN health agency said this was “good news” but cautioned that it was too early to make any predictions about whether the virus might have peaked. “There has […]
Novel theranostic reagent could enhance detection and therapy of prostate cancer
A recently discovered prostate cancer-selective antigen has been identified as a useful molecular imaging target for the detection and targeting of metastatic prostate cancer lesions, as reported in the November issue of The Journal of Nuclear Medicine. Using a novel radiotracer, researchers were able to effectively image STEAP1 (six-transmembrane epithelial antigen of prostate-1) in tumors […]
Machine learning leads to novel way to track tremor severity in Parkinson’s patients
One of the hallmarks of Parkinson’s disease (PD) is tremors. This involuntary movement disorder reduces quality of life by interrupting patients’ activities such as writing and eating. Neurologists routinely measure tremors using the Unified Parkinson’s Disease Rating Scale (UPDRS), which requires patients to perform specific tasks. Unfortunately, this evaluation is based on an onsite physical […]
Novel tool used to mine clinical data and identify causative gene in childhood epilepsy
A team of researchers at Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) discovered a new gene associated with severe childhood epilepsy using a novel computational approach. The team systematically compared phenotypes, or clinical data, of patients with severe childhood epilepsies through a novel analysis strategy and looked for common […]
When melanoma spreads to the brain, patients with BRAF or MEK mutations can find novel treatment
Cancer used to be thought of as a disease of the anatomy, but these days it increasingly is understood as a disease of the genes—one that theoretically can be treated with drugs engineered to target the genetic mutations driving a patient’s cancer. Melanoma, a type of skin cancer, is the fifth-most common cancer in the […]
Novel strategy appears to protect retina when disease reduces oxygen
An enzyme known to help our liver get rid of ammonia also appears to be good at protecting our retina, scientists report. Our retina, which captures light and converts it into neural signals that go to the brain so we can see, can be damaged or destroyed by conditions that reduce blood flow like diabetes, […]