Health News

Supposed disorder is not disorder after all

The researchers led by Profesoor Raphael Stoll therefore expect their results to form a basis for future therapeutic strategies to combat cancers caused by HMGA1a. They report in the journal Nucleic Acids Research on July, 24 2019. While the correct function of many proteins depends on their three-dimensional structure, some appear to adopt random forms. […]

Health News

Clues on how soils may respond to climate change found

Rock core samples from a period of warming millions of years ago indicate soils contributed to a rapid rise in atmospheric greenhouse gas and suggest modern climate models may overestimate Earth’s ability to mitigate future warming, according to an international team of scientists. Researchers discovered a drastic drop in organic material preserved in sections of […]

Health News

Shedding light on darker parts of our genetic heritage

More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses. Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the […]

Health News

How mutations lead to neurodegenerative disease

Scientists have discovered how mutations in DNA can cause neurodegenerative disease. The discovery is an important step towards better treatment to slow the progression or delay onset in a range of incurable diseases such as Huntington’s and motor neurone disease — possibly through the use, in new ways, of existing anti-inflammatory drugs. The team of […]

Health News

New technique for in-cell distance determination

In a joint paper which has just been published in The Journal of Physical Chemistry Letters, researchers from the University of Konstanz, Bielefeld University and ETH Zurich demonstrate for the first time that the electron paramagnetic resonance (EPR) technique RIDME (relaxation-induced dipolar modulation enhancement) can be applied to determine distances between gadolinium(III)-based spin labels in […]

Health News

Machine-learning model provides detailed insight on proteins

A novel machine-learning ‘toolbox’ that can read and analyse the sequences of proteins has been described today in the open-access journal eLife. The study demonstrates that, when trained to read sequence data, artificial neural networks called Restricted Boltzmann Machines (RBM) can provide a wealth of information on protein structure, function and evolutionary features. It is […]