Health News

Using circulating tumor DNA to detect urothelial cancer relapse could help improve treatment

Using circulating tumor DNA to identify patients at risk of urothelial cancer relapse after surgical resection could help improve post-surgery treatment, according to a study published in Nature. Patients who test positive for circulating tumor DNA (ctDNA) after surgery and who were treated with immunotherapy had improved disease-free survival compared to patients who were positive […]

Health News

UIC researchers offer free rapid diagnostic testing for COVID-19 in vulnerable Chicago communities

Researchers at the University of Illinois Chicago are offering free rapid diagnostic testing for COVID-19 in vulnerable Chicago communities and performing genomic sequencing on the samples to identify variants. The research is part of a National Institutes of Health-funded initiative called Rapid Acceleration of Diagnostics Underserved Populations, or RADx-UP. The UIC researchers are working to […]

Health News

DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

Researchers in the United States and Canada have identified DNA on/off “switches” within the angiotensin-converting enzyme 2 (ACE2) gene that may control the expression of this host cell receptor before, during and after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus is the agent responsible for the ongoing coronavirus disease 2019 […]

Health News

First-of-its-kind study identifies 13 new Alzheimer’s disease genes

In the first study to use whole genome sequencing (WGS) to discover rare genomic variants associated with Alzheimer's disease (AD), researchers have identified 13 such variants (or mutations). In another novel finding, this study establishes new genetic links between AD and the function of synapses, which are the junctions that transmit information between neurons, and […]

Health News

DNA spike-ins increase reliability of amplicon-based sequencing of SARS-CoV-2 genomes

As the coronavirus disease 2019 (COVID-19) pandemic continues to spread all over the world, its causative pathogen, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is being monitored for the emergence of new variants and alterations in viral biology. In the interests of cost-effectiveness and rapidity, amplicon-based sequencing of the viral genome has been used […]

Health Problems

What is Cancer?

Cancer refers to a group of more than a hundred diseases that can originate in many different parts of the body. However, the following features are common to all types of cancer: Abnormal cell growth Capacity to invade other tissues Capacity to spread to distant organs via blood vessels or lymphatic channels (metastasis) If cancer […]

Health Problems

Closed Circular DNA and Hepatitis B Infection

Hepatitis B virus (HBV) is a common cause for liver disease and accounts for approximately one million deaths worldwide every year. This virus is of the Hepadnaviridae family and its genome comprises of a partially double-stranded relaxed circular DNA (rcDNA). The genome of HBV exists in two forms, i.e., the circular covalently closed DNA (cccDNA) […]