In three recent publications in Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer’s disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials. “This is an […]
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Aging, diet-induced obesity, and metabolic disease link explored in new research
Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth). Telomeres act as protective caps at the end of chromosomes to prevent them from replication errors during […]
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Magenta Therapeutics and bluebird bio Announce a Phase 2 Clinical Trial Collaboration to Evaluate Magenta’s MGTA-145 for Mobilizing and Collecting Stem Cells in Adults and Adolescents with Sickle Cell Disease
CAMBRIDGE, Mass.–(BUSINESS WIRE)–Dec. 4, 2020– Magenta Therapeutics (NASDAQ: MGTA) and bluebird bio, Inc. (NASDAQ: BLUE) today announced an exclusive clinical trial collaboration to evaluate the utility of MGTA-145, in combination with plerixafor, for mobilization and collection of stem cells in adults and adolescents with sickle cell disease (SCD). The data from this clinical trial could provide proof-of-concept for MGTA-145, […]
Vaping raises lung disease risks by more than 40%, study finds
Vaping raises lung disease risks by more than 40%: Study finds young e-cigarette users face higher risks of asthma, chronic bronchitis and COPD Boston University researchers found that even among vapers who don’t smoke, risks of lung disease are 43% higher for current e-cig users Current vapers are 34% more at risk for chronic bronchitis and […]
Study reveals the impact of systemic inflammation on disease progression
Every year, liver cirrhosis is responsible for approximately 170,000 deaths in Europe and recent epidemiological data show Austria to be in second place in regard to prevalence of cirrhosis in Europe. Excessive alcohol consumption, poor dietary habits, and metabolic comorbidities are the most common causes of cirrhosis in the Western world. Liver cirrhosis is characterized […]
Diabetes increases neuritic damage around amyloid plaques in Alzheimer’s disease
New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer’s disease (AD). In an AD mouse model, diabetes induced through a diet rich in fats and sugars weakened the accumulation of microglial cells around amyloid plaques and increased the formation of neuritic plaques with […]
Genetics Tied to Thromboembolism Risk With Inflammatory Bowel Disease
WEDNESDAY, Nov. 18, 2020 — Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. 21 in Gastroenterology. Takeo Naito, Ph.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping […]
New technique isolates brain cells associated with Parkinson’s disease
Carnegie Mellon University researchers have developed a new technique for isolating a type of brain cell associated with Parkinson’s disease symptoms, enabling them to study that cell type in detail. The technique, which works only in specially bred mice, costs less than previous methods for isolating these brain cells, said Alyssa Lawler, a Ph.D. student […]
Seven different ‘disease forms’ identified in mild COVID-19
In a study recently published in the journal Allergy, a team of MedUni Vienna scientists led by immunologist Winfried F. Pickl and allergologist Rudolf Valenta (both from the Center for Pathophysiology, Infectiology and Immunology) showed that there are seven forms of disease in COVID-19 with mild disease course, and that the disease leaves behind significant […]