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Israeli study of breakthrough infections following full BNT-Pfizer vaccination, 40% immunocompromised

Severe forms of coronavirus disease (COVID-19) linked to high mortality rates might arise in a minority of fully-vaccinated individuals with many co-occurring medical conditions, finds a recent study by Israeli researchers published in the journal Clinical Microbiology and Infection. Study: BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully-vaccinated hospitalized COVID-19 patients in Israel. Image Credit: […]

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IL-6 Levels Tied to Progression of Diabetic Kidney Disease

Higher levels of interleukin-6 (IL-6) are associated with faster progression of proteinuric diabetic kidney disease, new research shows. In addition, higher IL-6 levels are not affected by drugs that block the renin–angiotensin–aldosterone (RAAS) system, which are widely used to treat the disease. “Diabetic kidney disease has classically been considered as a noninflammatory kidney disease and […]

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Senolytics reduce inflammation, illness, and mortality from COVID infection in older mice

Mayo Clinic researchers and colleagues at the University of Minnesota showed that COVID-19 exacerbates the damaging impact of senescent cells in the body. In preclinical studies, the senolytic drugs discovered at Mayo significantly reduced inflammation, illness, and mortality from COVID infection in older mice. The findings appear in the journal Science. Senescent cells (damaged or […]

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Could COVID-19 trigger chronic fatigue syndrome in the young?

Although older adults are among the most vulnerable to the ravages of COVID-19, new research warns that young patients can develop long-lasting fatigue and concentration problems, even if their COVID-19 infection was mild. That’s the troubling takeaway from three COVID-19 cases involving patients between the ages of 19 and 30. Investigators said they all developed […]

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Nephrologists Make the Case for Cystatin C-Based eGFR

A patient’s estimated glomerular filtration rate (eGFR) remains a pillar for diagnosing chronic kidney disease (CKD) and tracking its progression. But nephrologists now recognize that eGFR values based entirely on measurement of serum creatinine, the common approach, may be misleading because of nonrenal factors that can skew serum creatinine levels up or down. The solution, […]

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Study examines efficacy of Pfizer-BioNTech mRNA COVID-19 vaccine across demographic groups

Scientists across the world are racing against time to develop effective vaccines for severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) to contain the current coronavirus disease 2019 (COVID-19) pandemic. The phase III trial of the mRNA-based BNT162b2 COVID-19 vaccine showed 95% efficacy in preventing SARS-COV-2 infection. In this randomized placebo-controlled trial, the vaccine was found to […]