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Researchers probe ematopoietic stem cell post-transplantation complications

Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many children with both malignant and non-malignant conditions. Pericardial effusion—excess fluid around the heart—is a recognized complication following HSCT, but its incidence, risk factors and impact on mortality are not well defined. Carrie Kitko, MD, Justin Godown, MD, and colleagues used the Pediatric Health Information […]

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Adult stem cell study shows fish oil may help with depression

A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication. Using stem cells from adults with a clinical diagnosis of depression, the University of Illinois at Chicago researchers who conducted the study also found that fish […]

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New window into brain cell communication debuts

The Allen Institute today released its first—and the world’s largest—dataset of electrical brain activity gathered using Neuropixels, a new high-resolution silicon probe that can read out activity from hundreds of neurons simultaneously. These data capture billions of lightning-fast spikes of electrical communication sparked from nearly 100,000 neurons as laboratory mice see and respond to images […]

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By exploiting a feature of the immune system, researchers open the door for stem cell transplants to repair the brain

In experiments in mice, Johns Hopkins Medicine researchers say they have developed a way to successfully transplant certain protective brain cells without the need for lifelong anti-rejection drugs. A report on the research, published Sept. 16 in the journal Brain, details the new approach, which selectively circumvents the immune response against foreign cells, allowing transplanted […]

Health Problems

Giant cell arteritis occurs at similar rate in blacks, whites

(HealthDay)—Biopsy-proven giant cell arteritis (BP-GCA) occurs at a similar rate among white and black patients, according to a study published online Aug. 8 in JAMA Ophthalmology. Anna M. Gruener, B.M.B.S., from the Johns Hopkins Wilmer Eye Institute in Baltimore, and colleagues conducted a retrospective cohort study involving all 586 patients (28.5 percent black; 65.2 percent […]

Health Problems

Nutritional cues regulate pancreatic tumor’s ‘cell drinking’

Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging “fuel” through an alternative supply route, called macropinocytosis. Scientists are hopeful that blocking this process, often described as “cellular drinking,” could lead to tumor-starving drugs. First, however, fundamental information is needed—such as the invisible molecular signals that drive the process. Now, scientists from Sanford Burnham […]