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(HealthDay)—Death rates from Alzheimer’s disease are particularly high in the rural United States, a preliminary study finds, highlighting a need for health care resources in traditionally under-served areas. Researchers discovered that over the past two decades, rural areas in the Southeast have seen the highest death rates from Alzheimer’s, at 274 per 100,000 people. That’s […]
A new idea for treating Alzheimer’s disease could eradicate the toxic proteins most closely linked to cognitive decline in the places where they do the most damage, a study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests. The study was published online in Science Translational Medicine on May 26. Early in […]
A team of neuroscientists has identified a potential means to address the loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis in mice. Their findings, reported in the journal Science Signaling, reveal that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation. “This work is the first to […]
In three recent publications in Molecular Psychiatry, Brain and JAMA Neurology researchers from the University of Gothenburg provide convincing evidence that an in-house developed blood test for Alzheimer’s disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials. “This is an […]
(HealthDay)—Some older folks are still sharp as tacks and dementia-free well into their 80s and beyond. Now German researchers have uncovered a possible reason why: Their genes may help them fend off protein build-up in the brain. The finding is based on a study of brain images of 94 participants, all aged 80 or older. […]
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Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment, according to a study in the journal Neuron. LOAD is the most prevalent form of dementia among people over age 65, a […]
New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer’s disease (AD). In an AD mouse model, diabetes induced through a diet rich in fats and sugars weakened the accumulation of microglial cells around amyloid plaques and increased the formation of neuritic plaques with […]
Scientists at the Massachusetts General Hospital (MGH) have developed a molecular imaging probe to reveal Alzheimer’s disease (AD)-related γ-secretase in rodents and macaques with translational potentials in humans. γ-Secretase is a key player in the etiology of AD and a prime drug target for AD, whose brain regional expression and distribution have yet remain largely […]
In a recent study, experts estimate up to one-third of people attending specialist memory clinics could have a condition that is commonly mistaken for early dementia. In a paper published in the journal, Brain, UK academics and clinicians have collaborated to develop a diagnostic definition of the widely recognised but poorly understood condition, Functional Cognitive […]