A combinatorial gene therapy approach- one designed to inhibit inflammation and one targeting protection against cartilage degeneration—was shown to preserve articular cartilage better than each approach alone in animal models of both moderate and severe post-traumatic osteoarthritis. The therapeutic strategy included combined delivery of helper-dependent adenoviruses expressing interleukin-1 receptor antagonist (IL-1Ra) to block inflammation and PRG4 (lubricin) to promote pro-anabolic cartilage genes and decrease expression of catabolic genes, as reported in an article published in Human Gene Therapy.
The article entitled “Combinatorial Prg4 and Il-1ra Gene Therapy Protects Against Hyperalgesia and Cartilage Degeneration in Posttraumatic Osteoarthritis,” was coauthored by Adrianne Stone, Matthew W. Grol, Brendan H.L. Lee, and a team of researchers from Baylor College of Medicine, Houston, TX. The researchers used two surgical techniques to model moderate and severe post-traumatic osteoarthritis. They found that the combination gene therapy led to improved cartilage preservation compared to monotherapy in both animal models.
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