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Gluten intolerance is associated with increased mortality

In a large study, an increased mortality for a number of causes of death in individuals with celiac disease compared with healthy people it was found. Therefore, those who suffer from a gluten intolerance have a 20 percent higher risk of dying from cardiovascular disease, cancer, or respiratory diseases inherit.

Researchers from the Karolinska Institutet in Sweden and Columbia University in the USA showed that celiac disease (also called gluten-sensitive or gluten-induced enteropathy, intestinal infantilism, coeliac disease, Heubner-Herter disease) is associated with a significantly increased mortality. The results were recently presented in the prestigious journal “JAMA”.

50,000 of celiac cases are analysed

People with celiac disease have to die, according to a recent study, an increased risk of premature, although the awareness of the disease has increased in recent years, and access to gluten-free food has been improved. On the basis of regional data from the pathology departments of Sweden, which are linked with national health registers, the research team tested about 50,000 patients, and patients with celiac disease in connection with the risk of death.

Mortality increases in celiac disease by over 20 percent

In comparison to the control group, the total mortality was increased in the coeliac disease-Affected 21 percent. The relative increase in risk of Mortality in all age groups and is strongest among those in whom the disorder was diagnosed at the age of 18 to 39 years.

Celiac disease is often associated with long-term complications

“We know that celiac disease can cause a number of long-term complications that can affect the life expectancy, but this study examines a population at a time, in the awareness of celiac disease and the access to gluten-free food is widespread,” says Benjamin Lebwohl, the Director of Clinical research at the celiac disease center of Columbia University and first author of the study.

Long-term consequences of celiac disease

“However, we have found that celiac disease is associated with long-term consequences,” stresses good-bye. In comparison to the control group, the risk in coeliac disease-Affected was particularly high, to die of heart disease, cancer or a respiratory disease. In the first year after diagnosis, the risk was highest, but the increase in Risk persisted for ten years after diagnosis.

Inflammation seems to be responsible

“Celiac disease is characterized by inflammation, are in General bad for health,” adds Professor Jonas F. Ludvigsson, a pediatrician and corresponding author of the study. He finds the results of the analysis, therefore, is not surprising.

Why is the risk of death after diagnosis highest?

The fact that the risks were in the first year after diagnosis, at the highest, can, according to Ludvigsson several reasons. “The inflammation of the bowel is often most intense with the diagnosis around and before a gluten-free diet on the mucosal healing effect,” says the Professor. Another possible explanation is that the celiac disease is often discovered when the Affected goods from other reasons, very ill. (vb)

For more information on the subject, see the article: gluten Allergy (celiac disease) – symptoms, causes and treatment.